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Diseases

Genetic and Rare Diseases Information Center (GARD)

Ledderhose disease


Other Names for this Disease
  • Lederhose disease
  • Plantar fibromatosis
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Overview

Ledderhose disease is a type of plantar fibromatosis characterized by thickening of the foot's deep connective tissue.[1] While many individuals with Ledderhose disease do not experience symptoms, over time the condition may progress, causing considerable pain when walking.[1][2] Repeated trauma, long-term alcohol consumption, chronic liver disease, diabetes, and epilepsy have been reported in association with the development of this condition. Heredity is also a clear factor in many patients. Often, patients with Ledderhose disease also have other fibrosing conditions such as Dupuytren contracture, knuckle pads, or Peyronie disease.[1]  The exact prevalence of Ledderhose disease is unknown, with some studies stating it is rare[3], and others stating it is a common condition.[1]
Last updated: 2/24/2011

References

  1. Hougeir FG, Mascaro JM. Plantar Fibromatosis. eMedicine. July 12, 2010; http://emedicine.medscape.com/article/1061903-overview. Accessed 2/17/2011.
  2. Ledderhose's disease. Dupuytren Society. 2011; http://www.dupuytren-online.info/morbus_ledderhose.html. Accessed 1/28/2011.
  3. De Souza DF, Micaelo, L, Cuzzi T, and Ramos-e-Silva M. Ledderhose Disease: An Unusual Presentation. J Clin Aesthet Dermatol. 2010; 3:45-47. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945849/?tool=pubmed. Accessed 2/17/2011.
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In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for¬†information on rare diseases and orphan drugs.¬† Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Ledderhose disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Lederhose disease
  • Plantar fibromatosis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.