Other Names for this Disease
- Perthes disease
- Legg-Calve-Perthes syndrome
- Osteochondritis deformans
- Coxa plana
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Your QuestionIs Legg-Calve-Perthes disease an inherited condition?
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While most cases of Legg-Calve-Perthes Disease occur randomly for no apparent reason (sporadically) , both familial and isolated cases have been reported. In some families, the condition appears to be inherited in an autosomal dominant fashion. In others, polygenic (caused by multiple genes) or multifactorial (caused by multiple factors, such as genes and environment) inheritance appears to be involved. Mutations in the COL2A1 gene (12q12-q13.2) have recently been identified in familial cases of Legg-Calve-Perthes disease.
Last updated: 1/6/2011
- Legg Calve Perthes Disease. National Organization for Rare Disorders (NORD). 2002; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Legg%20Calve%20Perthes%20Disease. Accessed 1/6/2011.
- Legg-Calve-Perthes Disease. Online Mendelian Inheritance in Man (OMIM). 2010; http://www.ncbi.nlm.nih.gov/omim/150600. Accessed 1/6/2011.
- Wiig O. Legg-Calve-Perthes disease. Orphanet. 2009; http://www.orphanet.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=2380. Accessed 1/6/2011.