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Diseases

Genetic and Rare Diseases Information Center (GARD)

Leigh syndrome


Other Names for this Disease
  • LS
  • Subacute necrotizing encephalopathy
  • SNE
  • Necrotizing encephalopathy infantile subacute of Leigh
  • Leigh's necrotizing encephalopathy
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Treatment

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What treatment is available for Leigh syndrome?

No treatment has proven effective for all individuals with Leigh syndrome. However, some patients have benefited from high doses of thiamine, coenzyme-Q, or L-carnitine. Some studies have shown that patients with Leigh syndrome due to a deficiency in coenzyme Q may benefit the most from treatment with coenzyme-Q, resulting in almost complete recovery or significant improvement of neurological abnormalities.[1] Other treatment may be symptomatic.  For instance, pral sodium bicarbonate or sodium citrate may be prescribed to manage lactic acidosis.[2]
Last updated: 12/10/2008

References
  1. Finsterer J. Leigh and Leigh-Like Syndrome in Children and Adults. Pediatr Neurol. 2008;
  2. Leigh's Disease Information Page. National Institute of Neurological Disorders and Stroke. October 2008; http://www.ninds.nih.gov/disorders/leighsdisease/leighsdisease.htm. Accessed 10/5/2011.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Leigh syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • LS
  • Subacute necrotizing encephalopathy
  • SNE
  • Necrotizing encephalopathy infantile subacute of Leigh
  • Leigh's necrotizing encephalopathy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.