Other Names for this Disease
- Subacute necrotizing encephalopathy
- Necrotizing encephalopathy infantile subacute of Leigh
- Leigh's necrotizing encephalopathy
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No treatment has proven effective for all individuals with Leigh syndrome. However, some patients have benefited from high doses of thiamine, coenzyme-Q, or L-carnitine. Some studies have shown that patients with Leigh syndrome due to a deficiency in coenzyme Q may benefit the most from treatment with coenzyme-Q, resulting in almost complete recovery or significant improvement of neurological abnormalities. Other treatment may be symptomatic. For instance, pral sodium bicarbonate or sodium citrate may be prescribed to manage lactic acidosis.
Last updated: 12/10/2008
- Finsterer J. Leigh and Leigh-Like Syndrome in Children and Adults. Pediatr Neurol. 2008;
- Leigh's Disease Information Page. National Institute of Neurological Disorders and Stroke. October 2008; http://www.ninds.nih.gov/disorders/leighsdisease/leighsdisease.htm. Accessed 10/5/2011.
- Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.
- GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.
- ClinicalTrials.gov lists trials that are studying or have studied Leigh syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.