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Diseases

Genetic and Rare Diseases Information Center (GARD)

Li-Fraumeni syndrome


Other Names for this Disease
  • LFS1
  • Li Fraumeni syndrome
  • Sarcoma family syndrome of Li and Fraumeni
  • SBLA syndrome (Sarcoma, Breast, Leukemia, and Adrenal Gland)
Related Diseases
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Inheritance

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How is Li-Fraumeni syndrome inherited?

Li-Fraumeni syndrome (LFS) is inherited in an autosomal dominant manner.[1] This means that a person only needs a change (mutation) in one copy of the responsible gene in each cell to have LFS. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene; these cases occur in people with no history of the disorder in their family. A person with LFS has a 50% chance with each pregnancy of passing along the altered gene to his or her child.
Last updated: 5/4/2015

References
  1. Katherine Schneider, MPH, Kristin Zelley, MS, Kim E Nichols, MD, and Judy Garber, MD, MPH. Li-Fraumeni Syndrome. GeneReviews. April 2013; http://www.ncbi.nlm.nih.gov/books/NBK1311/.


Other Names for this Disease
  • LFS1
  • Li Fraumeni syndrome
  • Sarcoma family syndrome of Li and Fraumeni
  • SBLA syndrome (Sarcoma, Breast, Leukemia, and Adrenal Gland)
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.