Other Names for this Disease
- Sarcoma family syndrome of Li and Fraumeni
- SBLA syndrome (Sarcoma, Breast, Leukemia, and Adrenal Gland)
- Li Fraumeni syndrome
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Li-Fraumeni syndrome (LFS) is inherited in an autosomal dominant manner. This means that a person only needs a change (mutation) in one copy of the responsible gene in each cell to have LFS. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene; these cases occur in people with no history of the disorder in their family. A person with LFS has a 50% chance with each pregnancy of passing along the altered gene to his or her child.
Last updated: 5/4/2015
- Katherine Schneider, MPH, Kristin Zelley, MS, Kim E Nichols, MD, and Judy Garber, MD, MPH. Li-Fraumeni Syndrome. GeneReviews. April 2013; http://www.ncbi.nlm.nih.gov/books/NBK1311/.