Light chain deposition disease
Other Names for this Disease
- Light-chain deposition disease
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immune system, the body's system of protecting ourselves against infection. The body fights infection with antibodies. Antibodies are made up of small protein segments called light chains and heavy chains. People with LCDD make too many light chains which get deposited in many different tissues and organs of the body. While LCDD can occur in any organ, the kidneys are always involved. Deposits of light chains can also occur in the liver, heart, small intestine, spleen, skin, nervous system and bone marrow. Additionally, about 50-60% of patients with LCDD have multiple myeloma and 17% have a disease called monoclonal gammopathy of unknown significance (MGUS). Early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. The goal of treatment in patients with LCDD is to stop/decrease the production of light chains and damage to organs. Treatment options can include: autologous stem cell transplantation; a drug called Bortezomib; a class of drugs called immunomodulatory drugs; and kidney transplant.Light chain deposition disease (LCDD) involves the
Last updated: 5/11/2015
- Boppana S and RA Sacher. Light-Chain Deposition Disease. Medscape Reference. 06/17/2014; http://emedicine.medscape.com/article/202585-overview. Accessed 5/11/2015.
- Light Chain Deposition Disease. University of North Carolina Kidney Center. http://www.unckidneycenter.org/kidneyhealthlibrary/lightchain.html. Accessed 5/11/2015.
- The International Multiple Myeloma Foundation offers information on light chain deposition disease on their Web site. Click on the link above to view the information page.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Light chain deposition disease. Click on the link to view a sample search on this topic.