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Diseases

Genetic and Rare Diseases Information Center (GARD)

Malignant mixed Mullerian tumor


Other Names for this Disease
  • Carcinosarcoma
  • Mixed Mullerian tumor
  • Mixed tumor, Mullerian
  • MMMT
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

My mom passed away with MMT Uterine Cancer. The doctors tell me its very rare. I'm still unsure and wanted to know more about this cancer and if it is genetic.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is there a genetic cause of malignant mixed Mullerian tumor?

Presently, most mixed Mullerian tumors (MMMT) are thought to occur by chance without an association to a genetic predisposition.  There have been rare reports of MMMT of the uterus developing in individuals with Lynch syndrome, an inherited condition in which individuals have a genetic predisposition to develop certain cancers including uterine cancer.[1]  One article in the medical literature describes two cases of MMMT of the ovary in women with personal and family histories of breast cancer, and the authors state that these cases of MMMT of the ovary are suggestive of hereditary breast-ovarian cancer syndrome.  As such, these authors state that genetic testing should be considered in women with MMMT of the ovary.[2]  Overall, there is currently very little information about the cause of MMMT.
Last updated: 4/8/2015

What are the risk factors for malignant mixed Mullerian tumor (MMMT)?

Researchers have identified risk factors for the development of malignant mixed Mullerian tumor (MMMT) of the uterus. These risk factors include: never bearing a child, older age ( > 50 years old), obesity, exposure to estrogen and long-term use of tamoxifen.  Oral contraceptive use has been found to help lower the risk of developing a malignant mixed Mullerian tumor.[3]
Last updated: 4/8/2015

References
  • Lu KH, Daniels M. Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention. Familial Cancer. 2013; 12(2):273-277. http://www.ncbi.nlm.nih.gov/pubmed/23765559. Accessed 7/23/2014.
  • Lavie O, Longacre T, Segev Y, Husain A. Ovarian carcinosarcomas associated with prolonged use of tamoxifen: case reports. International Journal of Gynecological Cancer. 2009; 19(9):1521-1523. http://www.ncbi.nlm.nih.gov/pubmed/19955929. Accessed 4/8/2015.
  • Kanthan, Senger. Uterine Carcinosarcomas (Malignant Mixed Müllerian Tumours): A Review with Special Emphasis on the Controversies in Management. Obstetrics and Gynecology International. 2011; 10:1155. http://www.hindawi.com/journals/ogi/2011/470795/. Accessed 12/10/2012.
Other Names for this Disease
  • Carcinosarcoma
  • Mixed Mullerian tumor
  • Mixed tumor, Mullerian
  • MMMT
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.