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Diseases

Genetic and Rare Diseases Information Center (GARD)

Mantle cell lymphoma


Other Names for this Disease
  • LCM
  • Lymphoma, mantle cell
  • Mantle zone lymphoma
  • MCL
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Overview

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-Hodgkin’s lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. [1][2][3] Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone.[4] Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.[2][3]
Last updated: 7/20/2011

References

  1. Mantle Cell Lymphomas. Lymphomation. June 2011; http://www.lymphomation.org/type-MCL.htm. Accessed 7/11/2011.
  2. O’Connor OA and Vose JM. Mantle Cell Lymphoma: Getting the Facts. Lymphoma Research Foundation.. http://www.lymphoma.org/atf/cf/%7B0363CDD6-51B5-427B-BE48-E6AF871ACEC9%7D/MANTLE%20CELL.PDF. Accessed 7/11/2011.
  3. Non Hodgkin Lymphoma. American Cancer Society. October 2010; http://www.cancer.org/acs/groups/cid/documents/webcontent/003126-pdf.pdf. Accessed 7/11/2011.
  4. Mantle Cell Lymphoma. National Organization for Rare Disorders (NORD). February 2011; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Mantle%20Cell%20Lymphoma. Accessed 7/11/2011.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Mantle cell lymphoma. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • LCM
  • Lymphoma, mantle cell
  • Mantle zone lymphoma
  • MCL
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.