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Diseases

Genetic and Rare Diseases Information Center (GARD)

Mantle cell lymphoma


Other Names for this Disease
  • Lymphoma, mantle cell
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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What are the signs and symptoms of Mantle cell lymphoma?

Signs and symptoms of mantle cell lymphoma (MCL) may include swelling of the lymph nodes, fever, night sweats, weight loss, and fatigue. Some people have no to few signs of MCL leading to delayed diagnosis and treatment.[1][2]

Of note, people with MCL may be at an increased risk for gastrointestinal issues, such as obstruction, intussusception, and multiple intestinal polyps, as well as a very high white blood cell count.[3]
Last updated: 4/27/2016

The Human Phenotype Ontology provides the following list of signs and symptoms for Mantle cell lymphoma. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Hematological neoplasm 90%
Lymphadenopathy 90%
Anorexia 50%
Splenomegaly 50%
Weight loss 50%

Last updated: 5/1/2016

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. O’Connor OA and Vose JM. Mantle Cell Lymphoma: Getting the Facts. Lymphoma Research Foundation.. http://www.lymphoma.org/atf/cf/%7B0363CDD6-51B5-427B-BE48-E6AF871ACEC9%7D/MANTLE%20CELL.PDF. Accessed 7/11/2011.
  2. Adult Non-Hodgkin Lymphoma Treatment–Patient Version (PDQ®). National Cancer Insitute. March 3, 2016; http://www.cancer.gov/types/lymphoma/patient/adult-nhl-treatment-pdq. Accessed 4/27/2016.
  3. Freedman AS, Friedberg JW. Initial treatment of mantle cell lymphoma. In: Lister A. UpToDate. Waltham, MA: UpToDate; November 13, 2015; Accessed 4/27/2016.


Other Names for this Disease
  • Lymphoma, mantle cell
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.