Marchiafava Bignami disease
Other Names for this Disease
- Chronic Marchiafava-Bignami syndrome
- Acute Marchiafava-Bignami disease
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Most individuals diagnosed with Marchiafava Bignami disease (MBD) have a history of alcoholism and poor nutrition. How onset occurs (suddenly or chronically) and the range of clinical symptoms vary among affected individuals. Generally, the most common presentation includes personality change and psychomotor impairment. Some individuals present to the hospital with sudden onset of stupor or coma, and some present with seizures. Other individuals may have acute, subacute, or chronic onset of dementia and/or gait problems. Psychiatric disturbances, incontinence, hemiparesis, aphasia, and apraxia have also been described.
Last updated: 12/7/2012
- Jennifer Ault. Marchiafava-Bignami Disease. eMedicine. February 3, 2010; http://emedicine.medscape.com/article/1146086-overview#showall. Accessed 5/31/2011.
- Kumar N. Neurologic presentations of nutritional deficiencies. Neurol Clin. February 2010; 28(1):107-170. Accessed 10/14/2014.