Marchiafava Bignami disease
Other Names for this Disease
- Acute Marchiafava-Bignami disease
- Chronic Marchiafava-Bignami syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
In individuals who have recovered from Marchiafava Bignami disease (MBD), it is not clear whether improvement was a result of vitamin supplementation or merely a reflection of the disease's natural history. Treatment should generally focus on nutritional support and rehabilitation from alcoholism (when alcoholism is present). Various treatments, including those typically used for alcoholism in general, have been given to patients with MBD. Some have improved and some have not. The most common treatments are thiamine and other B vitamins (especially vitamin B-12 and folate, which is not a B vitamin but is commonly given with B-12). No specific proven treatment is available. It has been recommended that individuals who survive the disease receive rehabilitation and, if appropriate, alcohol and nutritional counseling.
Last updated: 6/1/2011
- Walter G. Bradley et al. Neurology in Clinical Practice, 5th ed.. USA: Butterworth-Heinemann; 2008 ;
- Jennifer Ault. Marchiafava-Bignami Disease. eMedicine. February 3, 2010; http://emedicine.medscape.com/article/1146086-overview#showall. Accessed 5/31/2011.
- Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.