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Diseases

Genetic and Rare Diseases Information Center (GARD)

McCune Albright syndrome


Other Names for this Disease
  • MAS
  • Albright syndrome
  • Albright's disease
  • PFD
  • POFD
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Cause

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What causes McCune Albright syndrome?

McCune Albright syndrome (MAS) is caused by a change (mutation) in the GNAS gene. This gene provides instructions for making part of a protein that ultimately influences many cell functions by regulating hormone activity. GNAS gene mutations that cause MAS result in a protein that causes the enzyme adenylate cyclase to be constantly turned on. This, in turn, leads to over-production of several hormones, resulting in the signs and symptoms of MAS.[1][2]
Last updated: 12/15/2015

References
  1. McCune-Albright syndrome. Genetics Home Reference (GHR). January 2009; http://ghr.nlm.nih.gov/condition=mccunealbrightsyndrome. Accessed 12/15/2015.
  2. GNAS Complex Locus. Online Mendelian Inheritance in Man – OMIM web site. September 29, 2014; http://omim.org/entry/139320. Accessed 12/15/2015.


Other Names for this Disease
  • MAS
  • Albright syndrome
  • Albright's disease
  • PFD
  • POFD
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.