McCune Albright syndrome
Other Names for this Disease
- Albright syndrome
- Albright's disease
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McCune Albright syndrome (MAS) is caused by a change (mutation) in the GNAS gene. This gene provides instructions for making part of a protein that ultimately influences many cell functions by regulating hormone activity. GNAS gene mutations that cause MAS result in a protein that causes the enzyme adenylate cyclase to be constantly turned on. This, in turn, leads to over-production of several hormones, resulting in the signs and symptoms of MAS.
Last updated: 12/15/2015
- McCune-Albright syndrome. Genetics Home Reference (GHR). January 2009; http://ghr.nlm.nih.gov/condition=mccunealbrightsyndrome. Accessed 12/15/2015.
- GNAS Complex Locus. Online Mendelian Inheritance in Man – OMIM web site. September 29, 2014; http://omim.org/entry/139320. Accessed 12/15/2015.