Mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes
Other Names for this Disease
- MELAS syndrome
- Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes
- Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
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How is mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) inherited?
MELAS is caused by mutations in mitochondrial DNA (mtDNA) and is therefore transmitted by maternal inheritance (also called mitochondrial inheritance). This type of inheritance applies to all conditions caused by genes in mtDNA. Mitochondria are structures in each cell that turn molecules into energy, and each contain a small amount of DNA. Only egg cells (not sperm cells) contribute mitochondria to offspring, so only females can pass on mitochondrial mutations to their children. Conditions resulting from mutations in mtDNA can appear in every generation of a family and can affect both males and females. In most cases, people with MELAS inherit an altered mitochondrial gene from their mother. Less commonly, the condition results from a new mutation in a mitochondrial gene and occurs in an individual with no history of MELAS in the family.
Last updated: 12/4/2013
- Salvatore DiMauro and Michio Hirano. MELAS. GeneReviews. November 21, 2013; http://www.ncbi.nlm.nih.gov/books/NBK1233/. Accessed 12/4/2013.
- Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. Genetics Home Reference. November 2006; http://ghr.nlm.nih.gov/condition/mitochondrial-encephalomyopathy-lactic-acidosis-and-stroke-like-episodes. Accessed 12/4/2013.