Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Print friendly version

Monoclonal gammopathy of undetermined significance

Información en español

Other Names for this Disease
  • MGUS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein called monoclonal protein is detected in the blood. MGUS typically does not cause any problems, although some affected people may experience numbness, tingling or weakness. In some cases, MGUS may progress over time to certain forms of blood cancer (such as multiple myeloma, macroglobulinemia, or B-cell lymphoma). MGUS is thought to be a multifactorial condition that is likely associated with the effects of multiple genes in combination with lifestyle and environmental factors. People with MGUS are usually monitored closely to ensure that the levels of monoclonal protein do not rise and other problems do not develop. Those with stable levels of monoclonal protein typically do not require treatment.[1][2]
Last updated: 5/8/2015

References

  1. Monoclonal gammopathy of undetermined significance (MGUS). Mayo Clinic. May 2013; http://www.mayoclinic.org/diseases-conditions/mgus/basics/definition/con-20026422.
  2. Suzanne R Fanning, DO. Monoclonal Gammopathies of Uncertain Origin. Medscape Reference. December 2014; http://emedicine.medscape.com/article/204297-overview#a0104.
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Contact GARD
Contact GARD
Contact a GARD Information Specialist with your questions about this condition.

Basic Information

  • The International Myeloma Foundation provides information on monoclonal gammopathy of undetermined significance.
  • MayoClinic.com has an information page on monoclonal gammopathy of undetermined significance. 
  • The Merck Manual provides information on this condition for patients and caregivers. 

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Merck Manual for health care professionals provides information on Monoclonal gammopathy of undetermined significance.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Monoclonal gammopathy of undetermined significance. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • MGUS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.