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Diseases

Genetic and Rare Diseases Information Center (GARD)

Mixed connective tissue disease


Other Names for this Disease
  • MCTD
  • Sharp syndrome
Related Diseases
  • Secondary glomerular disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis.[1] Although MCTD can affect people of all ages, it appears to be most common in women under age 30.[2] Signs and symptoms vary but may include Raynaud's phenomenon; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus.[3][1] The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresive drugs may help manage the symptoms.[2]
Last updated: 12/29/2014

References

  1. Eric L Greidinger, MD. Mixed Connective-Tissue Disease. Medscape Reference. February 2013; http://emedicine.medscape.com/article/335815-overview.
  2. Mixed Connective Tissue Disease. Mayo Foundation for Medical Education and Research. May 2012; http://www.mayoclinic.org/diseases-conditions/mixed-connective-tissue-disease/basics/definition/con-20026515?METHOD=print.
  3. Mixed Connective Tissue Disease (MCTD). NORD. October 2007; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/338/viewAbstract.
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Basic Information

  • The Mayo Clinic Web site has an information page on mixed connective tissue disease that can be found at the following link. Click on The Mayo Clinic to view the information page.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

Other Names for this Disease
  • MCTD
  • Sharp syndrome
Related Diseases
  • Secondary glomerular disease
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.