Mixed connective tissue disease
Other Names for this Disease
- Sharp syndrome
- Secondary glomerular disease
autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus, scleroderma, and polymyositis. Some affected people may also have symptoms of rheumatoid arthritis. Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids and immunosuppresive drugs may help manage the symptoms.Mixed connective tissue disease (MCTD) is a rare
Last updated: 12/29/2014
- Eric L Greidinger, MD. Mixed Connective-Tissue Disease. Medscape Reference. February 2013; http://emedicine.medscape.com/article/335815-overview.
- Mixed Connective Tissue Disease. Mayo Foundation for Medical Education and Research. May 2012; http://www.mayoclinic.org/diseases-conditions/mixed-connective-tissue-disease/basics/definition/con-20026515?METHOD=print.
- Mixed Connective Tissue Disease (MCTD). NORD. October 2007; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/338/viewAbstract.
- The Mayo Clinic Web site has an information page on mixed connective tissue disease that can be found at the following link. Click on The Mayo Clinic to view the information page.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
Mixed Connective-Tissue Disease
Pediatric Mixed Connective Tissue Disease
Dermatologic Manifestations of Mixed Connective Tissue Disease
- The Merck Manual for health care professionals provides information on Mixed connective tissue disease.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Mixed connective tissue disease. Click on the link to view a sample search on this topic.