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papules and nodules and associated with arthritis mutilans. The disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). In the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome.Multicentric reticulohistiocytosis is a disease that is characterized by the presence of
Last updated: 9/28/2012
- Chakravarty EF, Genovese MC. Chapter 111 -- Musculoskeletal Syndromes in Malignancy. Harris: Kelley’s Textbook of Rheumatology, 7th ed.. Philadelphia, PA: W.B. Saunders Company; 2005;
- West SG. Chapter 297 -- Systemic Diseases in Which Arthritis is a Feature. Goldman: Cecil Textbook of Medicine, 23rd ed.. Philadelphia, PA: Saunders Elsevier; 2008;
- Rapini RP, Morgan LT. Dermatologic Manifestations of Multicentric Reticulohistiocytosis . Medscape Reference . June 6, 2012; http://emedicine.medscape.com/article/1058248-overview. Accessed 9/28/2012.
- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Multicentric reticulohistiocytosis. Click on the link to view a sample search on this topic.