Other Names for this Disease
- Plasma cell myeloma
- Kahler disease
- Plasma cell dyscrasia
- Myeloma - multiple
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cancer that occurs due to abnormal and uncontrolled growth of plasma cells in the bone marrow. Some people with multiple myeloma, especially those with early stages of the condition, have no concerning signs or symptoms. When present, the most common symptom is anemia, which can be associated with fatigue and shortness of breath. Other features of the condition may include multiple infections; abnormal bleeding; bone pain; weak and/or easily broken bones; and numbness and/or weakness of the arms and legs. The exact underlying cause of multiple myeloma is currently unknown. Factors that are associated with an increased risk of developing multiple myeloma include increasing age, male sex, African American race, radiation exposure, a family history of the condition, obesity, and/or a personal history of monoclonal gammopathy of undetermined significance (MGUS). Treatment varies based on many factors, but may include one or more of the following interventions: chemotherapy, corticosteroid medications, targeted therapy, stem cell transplant, biological therapy, radiation therapy, surgery and/or watchful waiting.Multiple myeloma is a form of
Last updated: 3/12/2016
- Dhaval Shah, MD. Multiple Myeloma. Medscape Reference. February 2016; http://emedicine.medscape.com/article/204369-overview.
- Multiple Myeloma. American Cancer Society. January 2016; http://www.cancer.org/Cancer/MultipleMyeloma/DetailedGuide/index.
- Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment. National Cancer Institute. October 2015; http://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq.
- Multiple Myeloma. Mayo Clinic. December 2015; http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607.
- The American Cancer Society provides information on Multiple myeloma. Please click on the link to access this resource.
- Genetics Home Reference (GHR) contains information on Multiple myeloma. This website is maintained by the National Library of Medicine.
- Mayo Clinic has an information page on Multiple myeloma.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Multiple myeloma. Click on the link to view a sample search on this topic.
- Sonneveld P et al., Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group. Blood. 2016 Jun 16;127(24):2955-62.