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Diseases

Genetic and Rare Diseases Information Center (GARD)

Multiple myeloma


Other Names for this Disease
  • Plasma cell myeloma
  • Kahler disease
  • Myelomatosis
  • Plasma cell dyscrasia
  • Myeloma - multiple
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

Newline Maker

How might multiple myeloma be treated?

The treatment of multiple myeloma varies based on many factors including the age and general health of the affected person; the associated signs and symptoms; and the severity of the condition. In general, one or more of the following interventions may be used to treat multiple myeloma:[1][2][3]
The National Cancer Institute offers information regarding the management of multiple myeloma, including more specific information regarding the treatments outlined above. Please click on the link to access this resource.
Last updated: 3/10/2016

References
  1. Multiple Myeloma. American Cancer Society. January 2016; http://www.cancer.org/Cancer/MultipleMyeloma/DetailedGuide/index.
  2. Dhaval Shah, MD. Multiple Myeloma. Medscape Reference. February 2016; http://emedicine.medscape.com/article/204369-overview.
  3. Plasma Cell Neoplasms (Including Multiple Myeloma) Treatment. National Cancer Institute. October 2015; http://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq.


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Multiple myeloma. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

Medical Products

The medication(s) listed in the table(s) below have been approved by the Food and Drug Administration (FDA) for treatment of this condition. The FDA Office of Orphan Products Development designates "orphan products" for those that treat rare diseases affecting fewer than 200,000 Americans. The table(s) below may not be an exhaustive list of drugs or products used to treat this condition. There may be other products available that are not considered orphan products. To search for all FDA approved drugs, visit Drugs@FDA. You can find orphan products used to treat other conditions by searching the Orphan Drug Product Designation database.


Generic Name Melphalan
Trade Name
(Manufacturer Name)
Alkeran® (injection)
(Glaxo Wellcome Inc.)
Indication
The FDA has approved this product to be used in this manner.
For the palliative treatment of patients with multiple myeloma for whom oral melphalan is not appropriate.
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Doxorubicin HCL liposome injection
Trade Name
(Manufacturer Name)
Doxil® (injection)
(Centocor Ortho Biotech Inc.)
Indication
The FDA has approved this product to be used in this manner.
For use in combination with bortezomib for the treatment of patients with multiple myeloma who have not previously received bortezomib and have at least one prior therapy.
More Information about this product Drug Information Portal

Generic Name Daratumumab
Trade Name
(Manufacturer Name)
Humax(R)-Cd38
(Janssen Research & Development, LLC)
Indication
The FDA has approved this product to be used in this manner.
For the treatment of patients with multiple myeloma who have received at least 3 prior lines of therapy including a proteasome inhibitor and an immunomodulatory agent or are double refractory to a proteasome inhibitor and an immunomodulatory agent
More Information about this product Drug Information Portal

Generic Name Carfilzomib
Trade Name
(Manufacturer Name)
Kyprolis
(Onyx Therapeutics, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy.
More Information about this product Drug Information Portal

Generic Name Ixazomib citrate
Trade Name
(Manufacturer Name)
Ninlaro
(Millennium Pharmaceuticals)
Indication
The FDA has approved this product to be used in this manner.
Use in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.
More Information about this product Drug Information Portal

Generic Name Pomalidomide
Trade Name
(Manufacturer Name)
Pomalyst
(Celgene Corporation)
Indication
The FDA has approved this product to be used in this manner.
Treatment of patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on or within 60 days of completion of the last therapy.
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Lenalidomide
Trade Name
(Manufacturer Name)
Revlimid®
(Celgene Corporation)
Indication
The FDA has approved this product to be used in this manner.
For use in combination with dexamethasone for the treatment of multiple myeloma patients who have received at least one prior therapy.
More Information about this product Drug Information Portal

Generic Name Thalidomide
Trade Name
(Manufacturer Name)
Thalomid®
(Celgene Corporation)
Indication
The FDA has approved this product to be used in this manner.
Acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrences.
More Information about this product Drug Information Portal
Medline Plus Health Information

Generic Name Bortezomib
Trade Name
(Manufacturer Name)
Velcade®
(Millennium Pharmaceuticals, Inc.)
Indication
The FDA has approved this product to be used in this manner.
Treatment of multiple myeloma patients who have received at least one prior therapy. Treatment of patients with mantle cell lymphoma.
More Information about this product Drug Information Portal
Medline Plus Health Information

Other Names for this Disease
  • Plasma cell myeloma
  • Kahler disease
  • Myelomatosis
  • Plasma cell dyscrasia
  • Myeloma - multiple
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.