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Diseases

Genetic and Rare Diseases Information Center (GARD)

Multiple myeloma


Other Names for this Disease
  • Plasma cell myeloma
  • Kahler disease
  • Myelomatosis
  • Plasma cell dyscrasia
  • Myeloma - multiple
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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What are the signs and symptoms of Multiple myeloma?

In some cases, multiple myeloma is not associated with any signs and symptoms. When present, the most common symptom is anemia (low red blood cell count), which can be associated with fatigue, shortness of breath, and dizziness. Other features of the condition may include:[1][2][3]
  • Bone pain
  • Nausea
  • Constipation
  • Loss of appetite
  • Frequent infections
  • Weight loss
  • Excessive thirst
  • Weakness and/or numbness in the arms and legs
  • Confusion
  • Abnormal bleeding
  • Weak bones that may break easily
  • Difficulty breathing
Last updated: 3/9/2016

The Human Phenotype Ontology provides the following list of signs and symptoms for Multiple myeloma. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Abnormality of metabolism/homeostasis -
Autosomal recessive inheritance -
Multiple myeloma -
Somatic mutation -

Last updated: 7/1/2016

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Multiple Myeloma. MedlinePlus. February 2015; http://www.nlm.nih.gov/medlineplus/ency/article/000583.htm.
  2. Multiple Myeloma. American Cancer Society. January 2016; http://www.cancer.org/Cancer/MultipleMyeloma/DetailedGuide/index.
  3. S Vincent Rajkumar, MD. Clinical features, laboratory manifestations, and diagnosis of multiple myeloma. UpToDate. January 2016;


Other Names for this Disease
  • Plasma cell myeloma
  • Kahler disease
  • Myelomatosis
  • Plasma cell dyscrasia
  • Myeloma - multiple
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.