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Diseases

Genetic and Rare Diseases Information Center (GARD)

Myasthenia gravis


Other Names for this Disease
  • Acquired myasthenia
  • Autoimmune myasthenia gravis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

What does myasthenia gravis do to my body?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is myasthenia gravis?

Myasthenia gravis is a chronic autoimmune neuromuscular disease. It is characterized by varying degrees of weakness of the skeletal muscles of the body. Common symptoms include weakness of the muscles that control the eye and eyelid, facial expression, chewing, talking, and swallowing. Weakness tends to increase during periods of activity and improves after periods of rest.[1] The exact cause of myasthenia gravis is unknown. Some cases have been linked to tumors in the thymus gland.[2] Researchers believe that variations in particular genes (as yet, unknown) may increase the risk of developing this condition. It is likely that many factors contribute to the risk of developing this complex disorder.[3] While there is no cure for myasthenia gravis, treatment may allow for periods without symptoms (remission).[1][2]   
Last updated: 2/9/2016

What are the symptoms of myasthenia gravis?

Myasthenia gravis can affect any voluntary muscle. Voluntary muscles are the muscles that we directly control to make our body do things like walk, run, write, throw, lift, smile, and chew. In myasthenia gravis the most commonly affected muscles are the muscles that control eye and eyelid movement, facial expression, and swallowing. The degree of muscle weakness varies from person to person. People with more severe disease may have many muscles affected, including the muscles that control breathing. People with mild disease may have only one muscle group involved, such as the eye muscles.[1]

In general, signs and symptoms of myasthenia gravis may include a drooping of one or both eyelids (ptosis), blurred or double vision (diplopia), unstable or waddling gait, weakness in arms, hands, fingers, legs, and neck, a change in facial expression, difficulty in swallowing and shortness of breath, and impaired speech (dysarthria).[1]

People can develop myasthenia gravis at any age. For unknown reasons, it is most commonly diagnosed in women younger than age 40 and men older than age 60. It is uncommon in children, but some infants born to women with myasthenia gravis have signs and symptoms of the condition for the first few says or weeks of life. This temporary occurrence of symptoms is called transient neonatal myasthenia gravis.[3]
Last updated: 2/9/2016

What causes myasthenia gravis?

Myasthenia gravis is a type of autoimmune disorder. Autoimmune disorders occur when the immune system mistakenly attacks healthy tissue.[MedlinePlus] In myasthenia gravis, the body produces antibodies that block the muscle cells from receiving messages (neurotransmitters) from the nerve cells.[2][1][3]

The exact cause of myasthenia gravis is unknown. In some cases, it is linked to tumors or other abnormalities of the thymus (a gland the plays an important role in the immune system).[2][1][3] Researchers also believe that variations in particular genes (as yet unknown) may increase the risk of myasthenia gravis. Ultimately, many factors likely contribute to the risk of developing this complex disorder.[3] 
Last updated: 2/9/2016

How can I learn more about how myasthenia gravis affects my body?

MedlinePlus offers a comprehensive list of resources for myasthenia gravis. MedlinePlus is a Web site designed by the National Library of Medicine to help you research your health questions. The Myasthenia Gravis Foundation of America also has information related to this topic.

You can also use the navigation menu on the left hand side of this page to view many additional resources on myasthenia gravis.
Last updated: 2/9/2016

References
Other Names for this Disease
  • Acquired myasthenia
  • Autoimmune myasthenia gravis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.