Inflammatory myofibroblastic tumor
Other Names for this Disease
- Inflammatory pseudotumor
- Inflammatory fibrosarcoma
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mesentery. Signs and symptoms vary depending on the site of the tumor. Some people with an IMT are asymptomatic, while others may have nonspecific respiratory symptoms, fever, or pain. IMTs may recur, and occasionally become locally invasive and/or spread (metastasize) to other parts of the body. The underlying cause of IMTs is poorly understood. Some cases have been linked to translocations involving the ALK gene. Treatment involves surgical removal when possible, although there are reports of treatment with oral steroids and radiation therapy.An inflammatory myofibroblastic tumor (IMT) is an uncommon, presumably benign (non-cancerous) tumor made up of cells called myofibroblastic spindle cells. It usually develops in children or young adults, but can affect people of any age. An IMT can occur in almost any part of the body but is most commonly found in the lung, orbit (eye socket), peritoneum (lining of the abdominal cavity and internal organs), and
Last updated: 2/8/2016
- Coffin CM, Hornick JL, Fletcher CD. Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases. American Journal of Surgical Pathology. April 2007; 31(4):509-520. http://www.ncbi.nlm.nih.gov/pubmed/17414097.
- Jindal A, Bal A, Agarwal R. Inflammatory myofibroblastic tumor of the trachea in the pediatric age group: case report and systematic review of the literature. Journal of Bronchology and Interventional Pulmonology. January, 2015; 22(1):58-65. http://www.ncbi.nlm.nih.gov/pubmed/?term=25590486.
- Chun YS, Wang L, Nascimento AG, Moir CR, Rodeberg DA. Pediatric inflammatory myofibroblastic tumor: anaplastic lymphoma kinase (ALK) expression and prognosis. Pediatr Blood Cancer. November, 2005; 45(6):796-801. http://www.ncbi.nlm.nih.gov/pubmed/?term=15602716.
- Ales Tomazic, Diana Gvardijancic, Joze Maucec, and Matjaz Homan. Inflammatory myofibroblastic tumor of the pancreatic head – a case report of a 6 months old child and review of the literature. Radiol Oncol. September, 2015; 49(3):265-270. http://www.ncbi.nlm.nih.gov/pubmed/?term=26401132.
- ALK. Genetics Home Reference (GHR). March 2011; http://ghr.nlm.nih.gov/gene/ALK.
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