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Diseases

Genetic and Rare Diseases Information Center (GARD)

Nail-patella syndrome


Other Names for this Disease
  • NPS 1
  • Onychoosteodysplasia
  • Turner-Kieser syndrome
  • Fong disease
  • Osteo-Onychodysplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

I have two children affected by nail-patella syndrome. Would physiotherapy help stabilize their joints?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is nail-patella syndrome?

Nail-patella syndrome is an inherited condition characterized by abnormalities of the nails, knees, elbows, and pelvis. Some affected people may also experience problems in other areas of the body such as the kidneys and eyes. The severity of the condition and the associated signs and symptoms can vary significantly from person to person, even among members of the same family. Nail-patella syndrome is caused by changes (mutations) in the LMX1B gene and is inherited in an autosomal dominant manner.[1][2][3] Treatment is supportive and based on the signs and symptoms present in each person.[3][2]
Last updated: 2/2/2016

Can physical therapy be used to help stabilize the joints in people affected by nail-patella syndrome?

The joint problems associated with nail-patella syndrome may be helped by analgesics, physical therapy, splinting, and bracing. In severe cases, surgery may be recommended if other management strategies are not effective.[2][3932]
Last updated: 2/2/2016

References
Other Names for this Disease
  • NPS 1
  • Onychoosteodysplasia
  • Turner-Kieser syndrome
  • Fong disease
  • Osteo-Onychodysplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.