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Diseases

Genetic and Rare Diseases Information Center (GARD)

Nephrogenic diabetes insipidus


Other Names for this Disease
  • Diabetes insipidus nephrogenic
  • Diabetes insipidus nephrogenic type 1
  • Vasopressin-resistant diabetes insipidus
  • ADH resistant diabetes insipidus
  • Diabetes insipidus nephrogenic X-linked
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might nephrogenic diabetes insipidus be treated?

Management is usually best accomplished by a team of physicians and other healthcare professionals. The team may include a nutritionist, a pediatric (or adult) nephrologist or endocrinologist, and a clinical geneticist. The basis of management involves free access to drinking water and toilet facilities. Polyuria and polydipsia can be reduced up to 50% without disrupting appropriate levels of sodium in the blood through the use of thiazide diuretics hydrochlorothiazide, chlorothiazide) and/or other diuretics (i.e., potassium-sparing diuretic amiloride), dietary restriction of sodium, and nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, which can potentially improve the ability of the body to concentrate urine and reduce urine output.[1]
Last updated: 7/31/2011

References
  1. Knoers N. Nephrogenic Diabetes Insipidus. GeneReviews. 2010; http://www.ncbi.nlm.nih.gov/books/NBK1177/. Accessed 7/31/2011.


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Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.
  • Orphanet Emergency Guidelines is an article which is expert-authored and peer-reviewed that is intended to guide health care professionals in emergency situations involving this condition.  

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Nephrogenic diabetes insipidus. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query".
Other Names for this Disease
  • Diabetes insipidus nephrogenic
  • Diabetes insipidus nephrogenic type 1
  • Vasopressin-resistant diabetes insipidus
  • ADH resistant diabetes insipidus
  • Diabetes insipidus nephrogenic X-linked
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.