Neuroleptic malignant syndrome
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schizophrenia and other neurological, mental, or emotional disorders. Affected people may experience high fever, muscle stiffness, sweating, unstable blood pressure, altered mental status, and autonomic dysfunction. In most cases, the condition develops within the first 2 weeks of treatment with the drug; however, it may develop any time during the therapy period. The exact underlying cause of neuroleptic malignant syndrome is unknown. In some cases, more than one family member can be affected which suggests there may be a genetic component. Upon diagnosis of the condition, the neuroleptic or antipsychotic drug is generally discontinued under a physician's supervision. Medications and/or other interventions may also be recommended to manage symptoms.Neuroleptic malignant syndrome is a rare neurological condition that is caused by an adverse reaction to neuroleptic (tranquilizer) or antipsychotic drugs. These drugs are commonly prescribed for the treatment of
Last updated: 7/14/2015
- Neuroleptic Malignant Syndrome Information Page. National Institute for Neurological Disorders and Stroke. April 2014; http://www.ninds.nih.gov/disorders/neuroleptic_syndrome/neuroleptic_syndrome.htm.
- Theodore I Benzer, MD, PhD. Neuroleptic Malignant Syndrome. Medscape Reference. February 2015; http://emedicine.medscape.com/article/816018-overview#a4.
- Eelco FM Wijdicks, MD. Neuroleptic malignant syndrome. UpToDate. May 2014; Accessed 7/14/2015.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
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- The Merck Manual for health care professionals provides information on Neuroleptic malignant syndrome.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Neuroleptic malignant syndrome. Click on the link to view a sample search on this topic.