Familial hypertrophic cardiomyopathy
Other Names for this Disease
- Asymmetric septal hypertrophy
- Hereditary ventricular hypertrophy
- Idiopathic hypertrophic subaortic stenosis
- Cardiomyopathy familial hypertrophic
- Heritable hypertrophic cardiomyopathy
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arrhythmias, heart failure, and an increased risk of sudden death. Familial HCM may be caused by mutations in any of several genes and is typically inherited in an autosomal dominant manner. Treatment may depend on severity of symptoms and may include medications, surgical procedures, and/or an implantable cardioverter-defibrillator (ICD).Familial hypertrophic cardiomyopathy (HCM) is an inherited heart condition characterized by thickening of the heart muscle. The thickening most often occurs in the muscle wall that separates the left and right ventricles from each other (interventricular septum). This may restrict the flow of oxygen-rich blood from the heart, or it may lead to less efficient pumping of blood. Signs and symptoms can vary. While some people have no symptoms, others may have chest pain, shortness of breath, palpitations, lightheadedness, dizziness, and/or fainting. Even in the absence of symptoms, familial HCM can have serious consequences such as life-threatening
Last updated: 11/30/2015
- Familial hypertrophic cardiomyopathy. Genetics Home Reference. August, 2015; http://ghr.nlm.nih.gov/condition/familial-hypertrophic-cardiomyopathy.
- Hypertrophic cardiomyopathy. Mayo Clinic. February 18, 2015; http://www.mayoclinic.org/diseases-conditions/hypertrophic-cardiomyopathy/home/ovc-20122102.
- The American Heart Association has an information page on Familial hypertrophic cardiomyopathy. The American Heart Association is the nation’s oldest and largest voluntary organization dedicated to fighting heart disease and stroke.
- Genetics Home Reference (GHR) contains information on Familial hypertrophic cardiomyopathy. This website is maintained by the National Library of Medicine.
- The Mayo Clinic Web site provides further information on Familial hypertrophic cardiomyopathy.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Familial hypertrophic cardiomyopathy. Click on the link to view a sample search on this topic.
- Identification and Treatment of Sudden Death Conditions in Young Patients. A presentation by David Bradley, M.D., Director, Pediatric Heart Rhythm Service, CS Mott Children's Hospital. Assoicate Professor, Department of Pediatrics and Communicable Diseases, University of Michigan.