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Diseases

Genetic and Rare Diseases Information Center (GARD)

Ocular toxoplasmosis


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Overview

Ocular toxoplasmosis is an infection in the eye caused by the parasite, Toxoplasm a gondii.  Toxoplasmosis is the most common cause of eye inflammation in the world.  Toxoplamosis can be acquired or present at birth (congenital), having crossed the placenta from a newly infected mother to her fetus.  Most humans acquire toxoplasmosis by eating raw or undercooked meat, vegetables or milk products, or by coming into contact with infected cat litterbox or sandboxes. In humans, the infection usually causes no symptoms, and resolves without treatment in a few months.  In individuals with compromised immune systems, Toxoplasm a gondii can reactivate to cause disease.[3933]  

Reactivation of a congenital infection was traditionally thought to be the most common cause of ocular toxoplasmosis, but an acquired infection is now considered to be more common.[1]  A toxoplasmosis infection that affects the eye usually attacks the retina and initially resolves without symptoms.  However, the inactive parasite may later reactivate causing the ocular presentation of eye pain, blurred vision, and possibly permanent damage, including blindness.  Although most cases of toxoplasmosis resolve on their own, for some, inflammation can be treated with antibiotics and steroids.[2]
Last updated: 8/2/2011

References

  1. Gerwin B, Kimble J. Ophthalmic Pearls: Uveitis. American Academy Ophthalmology: EyeNet Magazine. 2011; http://www.aao.org/aao/publications/eyenet/200711/pearls.cfm. Accessed 8/1/2011.
  2. Toxoplasmosis. American Association for Pediatric Ophthalmology and Strabismus. 2011; http://www.aapos.org/terms/conditions/106. Accessed 7/28/2011.
  3. Wu L, Roy H, et al. Ophthalmologic Manifestations of Toxoplasmosis. E-medicine. January 10, 2011; http://emedicine.medscape.com/article/1204441-overview#showall. Accessed 7/25/2011.
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In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
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