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Diseases

Genetic and Rare Diseases Information Center (GARD)

Olivopontocerebellar atrophy


Other Names for this Disease
  • OPCA
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Overview

Olivopontocerebellar atrophy (OPCA) is a progressive condition characterized by the degeneration of nerve cells (neurons) in specific areas of the brain.[1] It occurs in several neurodegenerative diseases, including multiple system atrophy (MSA) and inherited and non-inherited forms of ataxia.[1] OPCA may also occur in people with prion disorders and inherited metabolic diseases.[1] The main symptom is clumsiness that slowly gets worse. Other symptoms may include problems with balance; speech or swallowing problems; difficulty walking; abnormal eye movements; muscle spasms; and neuropathy. Whether OPCA is inherited (and the inheritance pattern) depends on the underlying cause, if known.[2] There is no cure for OPCA, and management aims to treat symptoms and prevent complications.[1][3][2]
Last updated: 4/4/2016

References

  1. NINDS Olivopontocerebellar Atrophy Information Page. NINDS. April 16, 2014; http://www.ninds.nih.gov/disorders/opca/opca.htm.
  2. Olivopontocerebellar Atrophy. NORD. 2012; http://rarediseases.org/rare-diseases/olivopontocerebellar-atrophy/.
  3. Joseph V. Campellone. Olivopontocerebellar atrophy. MedlinePlus. July 27, 2014; http://www.nlm.nih.gov/medlineplus/ency/article/000758.htm.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Olivopontocerebellar atrophy. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • OPCA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.