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Diseases

Genetic and Rare Diseases Information Center (GARD)

Oral lichen planus


Other Names for this Disease
  • Oral lichenoid lesions
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Treatment

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How might oral lichen planus be treated?

It is important to identify and remove any potential agent that might have caused a lichenoid reaction.[1] Chemicals or medications associated with development of lichen planus include gold, antibiotics, arsenic, iodides, chloroquine, quinacrine, quinidine, antimony, phenothiazines, diuretics such as chlorothiazide, and many others.[2483] Consideration regarding role of drugs that were started in recent months prior to the on set of oral lichen planus, as well as any contact allergens identified by patch testing is recommended.[1]

Symptoms may improve with the following measures:[1]

Meticulous oral hygiene
Stopping smoking
Topical steroids as drops, pastes, gels or sprays (e.g., triamcinolone paste)
Steroid injections (intralesional triamcinolone)
Mouth rinse containing the calcineurin inhibitors: cyclosporin or tacrolimus

In severe cases systemic corticosteroids may be used.[1]

Other possible therapeutic agents may include:[1]

Thalidomide
Systemic retinoids (acitretin or isotretinoin)
Griseofulvin
Azathioprine
Cyclophosphamide
Dapsone
Metronidazole
Low molecular weight heparin

Last updated: 7/20/2011

References
  1. Oral Lichen Planus. New Zealand Dermatologic Soceity, inc.. Ocotber 2010; http://www.dermnet.org.nz/scaly/oral-lichen-planus.html. Accessed 7/20/2011.


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Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Oral lichen planus. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Oral lichenoid lesions
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.