Other Names for this Disease
- Anti-Jo1 syndrome
- AS syndrome
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Corticosteroids are typically the first-line of treatment and may be required for several months or years. These medications are often given orally; however, in severe cases, intravenous methylprednisolone may be prescribe initially. Immunosuppressive medications may also be recommended, especially in people with severe muscle weakness or symptomatic interstitial lung disease. According to recent studies, Rituximab is the medication option when patients with lung disease do not respond well to other treatments. Physical therapy is often necessary to improve weakness, reduce further muscle wasting from disuse, and prevent muscle contractures.
Last updated: 5/26/2016
- Antisynthetase syndrome. DermNet NZ. December 2014; http://dermnetnz.org/immune/antisynthetase.html.
- Chatterjee S, Prayson R, Farver C.. Antisynthetase syndrome: not just an inflammatory myopathy. Cleve Clin J Med. October 2013; 80(10):655-666.
- Sharp C, McCabe M, Dodds N, Edey A, Mayers L, Adamali H, Millar AB & Gunawardena H. Rituximab in autoimmune connective tissue disease-associated interstitial lung disease. Rheumatology (Oxford). April 8, 2016; pii: kew195. https://www.ncbi.nlm.nih.gov/pubmed/27060110.
- ClinicalTrials.gov lists trials that are studying or have studied Antisynthetase syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.