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Diseases

Genetic and Rare Diseases Information Center (GARD)

Peutz-Jeghers syndrome


Other Names for this Disease
  • Lentiginosis, perioral
  • Periorificial lentiginosis syndrome
  • Peutz Jeghers polyposis
  • PJS
  • Polyposis, hamartomatous intestinal
Related Diseases
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Inheritance

Newline Maker

Is Peutz-Jeghers syndrome inherited?

Peutz-Jeghers syndrome (PJS) is inherited in an autosomal dominant manner.[1] This means that to be affected, a person only needs a change (mutation) in one copy of the responsible gene in each cell. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene. These cases occur in people with no history of the disorder in their family. A person with PJS has a 50% chance with each pregnancy of passing along the altered gene to his or her child.
Last updated: 3/15/2014

References
  1. Thomas J McGarrity, MD, Christopher I Amos, PhD, Marsha L Frazier, PhD, and Chongjuan Wei, PhD. Peutz-Jeghers Syndrome. GeneReviews. July 2013; http://www.ncbi.nlm.nih.gov/books/NBK1266/.


Other Names for this Disease
  • Lentiginosis, perioral
  • Periorificial lentiginosis syndrome
  • Peutz Jeghers polyposis
  • PJS
  • Polyposis, hamartomatous intestinal
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.