Pigmented villonodular synovitis
Other Names for this Disease
- Localized pigmented villonodular synovitis
- Diffuse pigmented villonodular synovitis
- Tenosynovial giant cell tumors
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tendons in the body (synovium) grows abnormally. It is characterized by a noncancerous mass or tumor. There are two types of PVNS: the local or nodular form (where the tumor involves the tendons that support the joint, or in one area of the joint) and the diffuse form (where the entire lining of the joint is involved). Symptoms might include: pain, limitation of movement, and locking of the joint. In some cases, the normal joint structure can be destroyed. The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, wrist, and rarely the jaw. The average age of diagnosis for this condition is 35 years. The cause of PVNS is grossly unknown. Treatment involves surgery to remove the tumor and damaged portions of the synovium.Pigmented villonodular synovitis (PVNS) is a disease in which the tissue lining the joints and
Last updated: 4/4/2016
- John R McGrath. Pigmented Villonodular Synovitis Imaging. Medscape. October 21, 2015; http://emedicine.medscape.com/article/394649-overview.
- American Academy of Orthopaedic Surgeons (AAOS). Pigmented Villonodular Synovitis. OrthoInfo. November 2014; http://orthoinfo.aaos.org/topic.cfm?topic=a00506.
- Guo-ping Xie Nan Jiang, Chang-xiang Liang, Jian-chun Zeng, Zhi-yuan Chen, Qian Xu, Rui-zhen Qi, Yi-rong Chen, Bin Yu. Pigmented Villonodular Synovitis: A Retrospective Multicenter Study of 237 Cases. PLoS One. March 23, 2015; 10(3):http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370558/.
- The American Academy of Orthopaedic Surgeons offers information on Pigmented villonodular synovitis
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- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
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