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Diseases

Genetic and Rare Diseases Information Center (GARD)

Pigmented villonodular synovitis


Other Names for this Disease
  • Localized pigmented villonodular synovitis
  • Diffuse pigmented villonodular synovitis
  • Tenosynovial giant cell tumors
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Cause

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What causes pigmented villonodular synovitis?

The exact cause of pigmented villonodular synovitis (PVNS) is unknown.  Some doctors believe that it is similar to arthritis, arising from swelling (inflammation) of the joint tissue. Others believe it develops like a tumor, caused by cells growing and multiplying more quickly than usual.[1] The association between a history of trauma and the development of  PVNS is unclear. One study found that 56% of individuals with PVNS had a history of previous trauma, while other studies have found a much lower incidence.[2] 

There have been studies suggesting that PVNS could be caused by specific genetic changes in the cells lining the joint. More studies are needed to research this association. [3]
Last updated: 4/5/2016

References
  1. Mendenhall WM, Mendenhall CM, Reith JD, Scarborough MT, Gibbs CP, Mendenhall NP. Pigmented Villonodular Synovitis. American Journal of Clinical Oncology. 2006; 29:548-550. http://www.ncbi.nlm.nih.gov/pubmed/17148989.
  2. Guo-ping Xie Nan Jiang, Chang-xiang Liang, Jian-chun Zeng, Zhi-yuan Chen, Qian Xu, Rui-zhen Qi, Yi-rong Chen, Bin Yu. Pigmented Villonodular Synovitis: A Retrospective Multicenter Study of 237 Cases. PLoS One. March 23, 2015; 10(3):http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370558/.
  3. Ravi V, Wang WL, Lewis VO. Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. Current Opinion in Oncology. 2011; 23:361-366. http://www.ncbi.nlm.nih.gov/pubmed/21577109. Accessed 11/22/2011.


Other Names for this Disease
  • Localized pigmented villonodular synovitis
  • Diffuse pigmented villonodular synovitis
  • Tenosynovial giant cell tumors
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.