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Genetic and Rare Diseases Information Center (GARD)

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POEMS syndrome


Other Names for this Disease
  • Crow-Fukase syndrome
  • Osteosclerotic myeloma
  • PEP syndrome
  • Polyneuropathy - endocrinopathy - plasma cell dyscrasia
  • Polyneuropathy organomegaly
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Overview

POEMS syndrome is a rare, mulitisystem disorder. POEMS stands for the disorder's features, which may include Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes. Signs and symptoms may include progressive sensorimotor polyneuropathy; enlarged liver, spleen, and/or lymph nodes; a disorder of the endocrine glands (often with multiple abnormalities); a monoclonal plasma cell proliferative disorder; and darkening of the skin (hyperpigmentation). Various other symptoms may also occur and may vary among affected people. The underlying cause of the disorder is not well understood. POEMS syndrome is a chronic disorder, with a median survival time of 8-14 years. There is no standard treatment; management depends on the underlying plasma cell disorder and may include radiation therapy, chemotherapy, and/or hematopoietic cell transplantation.[1]
Last updated: 7/20/2015

References

  1. POEMS syndrome. DermNet NZ. September 13, 2014; http://dermnetnz.org/systemic/poems.html.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • The Merck Manual provides information on this condition for patients and caregivers. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
  • TheDoctorsDoctor provides information on this condition. TheDoctorsDoctor is an online resource developed by pathologists. Click on TheDoctorsDoctor to view the information page.
  • The MayoClinic Web site provides information on this topic. Click on MayoClinic to access the information page on POEMS syndrome.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Merck Manual for health care professionals provides information on POEMS syndrome.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss POEMS syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Crow-Fukase syndrome
  • Osteosclerotic myeloma
  • PEP syndrome
  • Polyneuropathy - endocrinopathy - plasma cell dyscrasia
  • Polyneuropathy organomegaly
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.