Progressive multifocal leukoencephalopathy
Other Names for this Disease
- Leukoencephalopathy, progressive multifocal
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myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but it rarely causes symptoms unless the immune system becomes severely weakened. The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as Hodgkin’s disease, lymphoma, and sarcoidosis. PML is most common among individuals with acquired immune deficiency syndrome (AIDS).Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the
Last updated: 4/1/2011
- Dugdale DC, Jasmin L. Progressive multifocal leukoencephalopathy. MedlinePlus. 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000674.htm. Accessed 3/3/2011.
- Koralnik IJ. Progressive Multifocal Leukoencephalopathy. National Organization for Rare Disorders (NORD). 2010; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Progressive%20Multifocal%20Leukoencephalopathy. Accessed 3/3/2011.
- NINDS Progressive Multifocal Leukoencephalopathy Information Page. National Institute of Neurological Disorders and Stroke (NINDS). 2010; http://www.ninds.nih.gov/disorders/pml/pml.htm. Accessed 3/3/2011.
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- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
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