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Diseases

Genetic and Rare Diseases Information Center (GARD)

Progressive supranuclear palsy


Other Names for this Disease
  • Supranuclear palsy, progressive
  • PSP
  • Steele-Richardson-Olszewski Syndrome
  • Familial progressive supranuclear palsy (type)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might progressive supranuclear palsy be treated?

There are currently no treatments that alter the course of disease for people with progressive supranuclear palsy (PSP), and no drugs that provide significant relief of symptoms.[1] However, supportive treatment may be helpful and may include:
  • Management of dysphagia and dysarthria with the help of dietitians as well as speech and language therapists
  • Early occupational therapy to promote longer independence in performing activities of daily living
  • The use of mirror-prism lenses for those with severe limitation of extraocular movements to read and feed themselves
  • The use of eyelid crutches, alone or in combination with botox therapy, for inability to open the eyes and blepharospasm
  • Physical therapy for symptomatic treatment of postural instability and falls, including gait and balance training[1]

A surgical procedure called a gastrostomy may be necessary when there are swallowing disturbances or a high risk of severe choking.[2]

Last updated: 1/29/2016

References
  1. Stewart A Factor, Christine Doss Esper. Progressive supranuclear palsy (PSP). UpToDate. Waltham, MA: UpToDate; December, 2015;
  2. Progressive Supranuclear Palsy Fact Sheet. NINDS. November 5, 2015; http://www.ninds.nih.gov/disorders/psp/detail_psp.htm.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Progressive supranuclear palsy. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Supranuclear palsy, progressive
  • PSP
  • Steele-Richardson-Olszewski Syndrome
  • Familial progressive supranuclear palsy (type)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.