Other Names for this Disease
- Succinylcholine Sensitivity
- Apnea, Postanesthetic
- Cholinesterase 2 Deficiency
- Pseudocholinesterase E1
- Suxamethonium Sensitivity
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autosomal recessive manner and caused by mutations in the BCHE gene, or it can have non-genetic causes in which case it is called acquired pseudocholinesterase deficiency.Pseudocholinesterase deficiency is a condition that causes increased sensitivity to certain muscle relaxant drugs used during general anesthesia, called choline esters. These drugs relax the muscles used for movement, including the muscles needed for breathing. They are normally broken down by the body within a few minutes of being given, at which time the muscles can move again. However, people with pseudocholinesterase deficiency may not be able to move or breathe on their own for a few hours after, therefore needing mechanical ventilation until the drugs are cleared from the body. Affected individuals may also have increased sensitivity to certain other drugs and to specific agricultural pesticides. Pseudocholinesterase deficiency can be inherited in an
Last updated: 10/16/2013
- Pseudocholinesterase deficiency. Genetics Home Reference. April 2012; http://ghr.nlm.nih.gov/condition/pseudocholinesterase-deficiency. Accessed 2/27/2014.
- Genetics Home Reference (GHR) contains information on Pseudocholinesterase deficiency. This website is maintained by the National Library of Medicine.
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- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
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- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Pseudocholinesterase deficiency. Click on the link to view a sample search on this topic.