Pure red cell aplasia
Other Names for this Disease
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bone marrow. Bone marrow contains stem cells which develop into the red blood cells that carry oxygen through the body, the white blood cells that fight infections, and the platelets that help with blood clotting. In people with PRCA, the bone marrow makes a reduced number of red blood cells (called anemia). As a result, affected people may experience fatigue, lethargy, and pale skin. PRCA has many different causes. A rare congenital form of PRCA, called Diamond Blackfan syndrome, is an inherited condition that is also associated with other physical abnormalities. PRCA can also be due to certain medications, infections, pregnancy, renal failure, and conditions such as thymomas, autoimmune disease (such as systemic lupus erythematosus), cancers of the blood, and solid tumors. In many cases, the cause of the condition is unknown (idiopathic). The treatment of PRCA aims to address the underlying cause of the condition and relieve the associated signs and symptoms.Pure red cell aplasia (PRCA) is a rare condition that affects the
Last updated: 4/21/2016
- Paul Schick, MD. Pure Red Cell Aplasia. Medscape Reference. February 2015; http://emedicine.medscape.com/article/205695-overview.
- Pure Red Cell Aplasia, Acquired. NORD. 2007; http://rarediseases.org/rare-diseases/pure-red-cell-aplasia-acquired/.
- Stanley L Schrier, MD. Acquired pure red cell aplasia in the adult. UpToDate. July 2015;
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Pure red cell aplasia. Click on the link to view a sample search on this topic.