Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Pure red cell aplasia


Other Names for this Disease
  • PRCA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Pure red cell aplasia (PRCA) is a rare condition that affects the bone marrow. Bone marrow contains stem cells which develop into the red blood cells that carry oxygen through the body, the white blood cells that fight infections, and the platelets that help with blood clotting. In people with PRCA, the bone marrow makes a reduced number of red blood cells (called anemia). As a result, affected people may experience fatigue, lethargy, and pale skin.[1][2] PRCA has many different causes. A rare congenital form of PRCA, called Diamond Blackfan syndrome, is an inherited condition that is also associated with other physical abnormalities. PRCA can also be due to certain medications, infections, pregnancy, renal failure, and conditions such as thymomas, autoimmune disease (such as systemic lupus erythematosus), cancers of the blood, and solid tumors. In many cases, the cause of the condition is unknown (idiopathic).[1][3] The treatment of PRCA aims to address the underlying cause of the condition and relieve the associated signs and symptoms.[1]
Last updated: 4/21/2016

References

  1. Paul Schick, MD. Pure Red Cell Aplasia. Medscape Reference. February 2015; http://emedicine.medscape.com/article/205695-overview.
  2. Pure Red Cell Aplasia, Acquired. NORD. 2007; http://rarediseases.org/rare-diseases/pure-red-cell-aplasia-acquired/.
  3. Stanley L Schrier, MD. Acquired pure red cell aplasia in the adult. UpToDate. July 2015;
GARD Video Tutorials
GARD Video Tutorials
Learn how to find information on treatment, research, specialists, and more.
Contact GARD
Contact GARD
Contact a GARD Information Specialist with your questions about this condition.

Basic Information

  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Pure red cell aplasia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • PRCA
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.