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Diseases

Genetic and Rare Diseases Information Center (GARD)

Renal glycosuria


Other Names for this Disease
  • Renal glucosuria
  • Familial renal glucosuria
  • SGLT2 deficiency
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Your Question

I have renal glycosuria with normal blood glucose levels and normal renal function. Is treatment necessary?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is renal glycosuria?

Renal glycosuria is a rare condition in which glucose is excreted in the urine despite normal or low blood glucose levels. With normal kidney function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood. However, in people with renal glycosuria, glucose is abnormally eliminated in the urine due to improper functioning of the renal tubules, which are the primary components of the filtering units of the kidneys.[1] In most people with renal glycosuria, there are no apparent symptoms or serious effects. Rare cases of polyuria (increased urine output), enuresis (involuntary urination), and mild growth and pubertal maturational delay have been reported. When renal glycosuria occurs as an isolated finding with otherwise normal kidney function, the condition is thought to be inherited in an autosomal recessive manner, caused by mutations in the  SLC5A2 gene. Treatment is not typically needed.[2]
Last updated: 1/20/2016

How might renal glycosuria be treated?

In most affected individuals, no treatment is required. However, some individuals with renal glycosuria may develop diabetes mellitus. Therefore, appropriate testing should be conducted to rule out diabetes and to regularly monitor those with confirmed renal glycosuria.[1]
Last updated: 1/20/2016

References
Other Names for this Disease
  • Renal glucosuria
  • Familial renal glucosuria
  • SGLT2 deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.