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Diseases

Genetic and Rare Diseases Information Center (GARD)

Sezary syndrome


Other Names for this Disease
  • Sézary lymphoma
  • Sézary syndrome
  • Sezary's lymphoma
Related Diseases
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Overview

Sezary syndrome is an aggressive form of cutaneous T-cell lymphoma which is a group of disorders that occur when T-cells (a type of white blood cell) become cancerous and affect the skin. It is characterized by a widespread red rash that may cover most of the body, the presence of cancerous T cells (called Sezary cells) in the blood, and abnormally enlarged lymph nodes. Other signs and symptoms may include intense itchiness, scaling and peeling of the skin; fever; weight loss; hair loss; outward turning of the eyelids (ectropion); palmoplantar keratoderma; malformation of the nails; and hepatosplenomegaly. The exact cause of Sezary syndrome is currently unknown. Treatment varies based on the signs and symptoms present in each person and the severity of the condition.[1][2]
Last updated: 8/3/2015

References

  1. Lauren C Pinter-Brown, MD. Cutaneous T-Cell Lymphoma. Medscape Reference. March 2015; http://emedicine.medscape.com/article/2139720-overview#showall.
  2. Mycosis Fungoides and the Sézary Syndrome Treatment (PDQ®). National Cancer Institute. May 2015; http://www.cancer.gov/types/lymphoma/patient/mycosis-fungoides-treatment-pdq.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • Genetics Home Reference (GHR) contains information on Sezary syndrome. This website is maintained by the National Library of Medicine.
  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Sezary syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Sézary lymphoma
  • Sézary syndrome
  • Sezary's lymphoma
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.