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Diseases

Genetic and Rare Diseases Information Center (GARD)

Stevens-Johnson syndrome


Other Names for this Disease
  • Erythema multiforme major
  • SJS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Stevens-Johnson Syndrome (SJS), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. This disorder affects the skin, mucous membranes and eyes.[1][2] Stevens-Johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age. Having a gene called HLA-B 1502, increases risk of having Stevens-Johnson syndrome.[1] It is an emergency medical condition that usually requires hospitalization. Treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications and includes pain medication to reduce discomfort, medication to relieve itching (antihistamines), antibiotics to control infection, when needed and medication to reduce skin inflammation (topical steroids).[3]
Last updated: 7/8/2015

References

  1. Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). May 2013; http://www.nei.nih.gov/health/cornealdisease/#m. Accessed 7/8/2015.
  2. Roujeau JC. Stevens-Johnson syndrome. Orphanet. 2009; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=36426. Accessed 3/15/2010.
  3. Stevens-Johnson syndrome. MayoClinic.com. April 22, 2014; http://www.mayoclinic.com/health/stevens-johnson-syndrome/DS00940/METHOD=print. Accessed 7/8/2015.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Stevens-Johnson syndrome. This website is maintained by the National Library of Medicine.
  • MayoClinic.com has an information page on Stevens-Johnson syndrome.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic. 

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
    Stevens-Johnson syndrome
    Dermatologic Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
    Erythema Multiforme
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Stevens-Johnson syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Erythema multiforme major
  • SJS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.