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Genetic and Rare Diseases Information Center (GARD)

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Stevens-Johnson syndrome


Other Names for this Disease
  • Dermatostomatitis, Stevens Johnson type
  • Erythema multiforme major
  • SJS
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Overview

Stevens-Johnson Syndrome (SJS), also called erythema multiforme major, is a limited form of toxic epidermal necrolysis. This disorder affects the skin, mucous membranes and eyes.[1][2] Stevens-Johnson syndrome occurs twice as often in men as women, and most cases appear in children and young adults under 30, although it can develop in people at any age. Having a gene called HLA-B 1502, increases risk of having Stevens-Johnson syndrome.[1] It is an emergency medical condition that usually requires hospitalization. Treatment focuses on eliminating the underlying cause, controlling symptoms and minimizing complications and includes pain medication to reduce discomfort, medication to relieve itching (antihistamines), antibiotics to control infection, when needed and medication to reduce skin inflammation (topical steroids).[3]
Last updated: 7/8/2015

References

  1. Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). May 2013; http://www.nei.nih.gov/health/cornealdisease/#m. Accessed 7/8/2015.
  2. Roujeau JC. Stevens-Johnson syndrome. Orphanet. 2009; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=36426. Accessed 3/15/2010.
  3. Stevens-Johnson syndrome. MayoClinic.com. April 22, 2014; http://www.mayoclinic.com/health/stevens-johnson-syndrome/DS00940/METHOD=print. Accessed 7/8/2015.
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Basic Information

  • MayoClinic.com has an information page on Stevens-Johnson syndrome.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic. 

In Depth Information

Other Names for this Disease
  • Dermatostomatitis, Stevens Johnson type
  • Erythema multiforme major
  • SJS
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.