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Diseases

Genetic and Rare Diseases Information Center (GARD)

Gastric cancer


Other Names for this Disease
  • Stomach cancer
  • Adult stomach cancer
  • Adult stomach carcinoma
  • Stomach carcinoma
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Overview

Gastric cancer is a form of cancer that occurs due to abnormal and uncontrolled cell growth in the stomach. Most people with early gastric cancer have no signs or symptoms of the condition. In advanced stages, symptoms may include indigestion; nausea and vomiting; difficulty swallowing; feeling full after eating small amounts of food; loss of appetite; vomiting blood; fatigue; and/or weight loss. Most cases of gastric cancer occur sporadically in people with little to no family history of the condition; however, approximately 10% of gastric cancers are considered "familial." Although the underlying cause of some familial cases is unknown, genetic changes (mutations) are identified in a subset of people affected by gastric cancer. Hereditary cancer syndromes associated with a predisposition to gastric cancer include hereditary diffuse gastric cancer, Lynch syndrome, Li-Fraumeni syndrome, familial adenomatous polyposis, and Peutz-Jeghers syndrome. In other families, the cluster of stomach cancers may be due to a combination of gene(s) and/or other shared factors such as environment and lifestyle. The best treatment options for gastric cancer depend on many factors including the stage of the condition, but may include surgery, chemotherapy, radiation therapy, and/or targeted therapy (such as monoclonal antibody therapy).[1][2]
Last updated: 12/15/2015

References

  1. Cabebe EC. Gastric Cancer. Medscape Reference. November, 2015; http://emedicine.medscape.com/article/278744-overview.
  2. Stomach (Gastric) Cancer—Patient Version. National Cancer Institute. June 2015; http://www.cancer.gov/types/stomach.
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Basic Information

  • The American Cancer Society provides information on Gastric cancer. Please click on the link to access this resource.
  • Mayo Clinic has an information page on Gastric cancer.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Gastric cancer. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Stomach cancer
  • Adult stomach cancer
  • Adult stomach carcinoma
  • Stomach carcinoma
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.