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Diseases

Genetic and Rare Diseases Information Center (GARD)

Synovial sarcoma


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Cause

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What causes synovial sarcoma?

The exact underlying cause of synovial sarcoma is poorly understood. However, studies show that a certain genetic change is identified in more than 90% of cases. More specifically, a translocation between chromosome X and chromosome 18 appears to play a role in the development of synovial sarcoma. This alteration is known as a somatic mutation because it only develops in some cells of the body during a person's lifetime and is not inherited.[1]

Certain inherited conditions such as Li Fraumeni syndrome or neurofibromatosis type 1 are associated with an increased risk of developing synovial sarcoma and other forms of soft tissue sarcoma. Some studies suggest that exposure to radiation therapy and/or certain chemical carcinogens may also be risk factors for soft tissue sarcoma.[2]
Last updated: 9/9/2015

References
  1. Bernardo Vargas, MD. Synovial Cell Sarcoma. Medscape Reference. November 2014; http://emedicine.medscape.com/article/1257131-overview.
  2. Christopher W Ryan, MD; Janelle Meyer, MD. Clinical presentation, histopathology, diagnostic evaluation, and staging of soft tissue sarcoma. UpToDate. January 2015; Accessed 9/9/2015.


See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.