- Wagner syndrome type 1
- Wagner vitreoretinal degeneration
- Hyaloideoretinal degeneration of Wagner
- Erosive vitreoretinopathy
Wagner syndrome is a hereditary eye disease characterized by a central vitreous cavity which appears empty on slit-lamp examination. The condition was named after the Swiss ophthalmologist Hans Wagner, who described a family with this condition in 1938. Since then less than 50 families have been described. The first signs usually emerge during early adolescence, but onset may be as early as age 2. Wagner syndrome is caused by mutations in the VCAN gene. It is inherited in an autosomal dominant manner.
- Van Aerde K, Kloeckener-Gruissem B. Wagner Syndrome. Wagner Syndrome Website. 2009; http://www.wagnersyndrome.eu/wagner.html. Accessed 12/7/2009.
- Kloeckener-Gruissem B, Amstutz C. VCAN-Related Vitreoretinopathy. GeneReviews. 2009; http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=wagner. Accessed 12/7/2009.
- Edery P. Wagner disease. Orphanet. 2004; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=898. Accessed 12/7/2009.
On this page
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Wagner syndrome. Click on the link to view a sample search on this topic.