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Diseases

Genetic and Rare Diseases Information Center (GARD)

Waldenstrom macroglobulinemia


Other Names for this Disease
  • Waldenstrom's macroglobulinaemia
  • Lymphoplasmacytic lymphoma
  • Waldenstrom's syndrome
  • Macroglobulinemia of Waldenstrom
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder.[1] It usually affects older adults and is primarily found in the bone marrow, although lymph nodes and the spleen may be involved. Affected individuals have a high level of an antibody called immunoglobulin M (IgM) in their blood, which can cause thickening of the blood (hyperviscosity).[2] Although some individuals initially do not have symptoms and are diagnosed from routine blood work, common symptoms may include weakness, appetite loss and weight loss. Other symptoms may include peripheral neuropathy, fever, Raynaud's phenomenon, and mental status changes.[1] Hyperviscosity of the blood may cause nosebleeds, headaches, dizziness, and blurring or loss of vision.[2] The cause of the condition is not known but environmental, genetic, and viral factors have been suggested. There have been some reports of familial cases suggesting a genetic predisposition. Treatment is often reserved for those with symptoms and may include various medications including corticosteroids, alkylating agents, biologic response modifiers and purine analogues.[1]
Last updated: 10/1/2013

References

  1. Karen Seiter. Waldenstrom Macroglobulinemia. Medscape Reference. January 31, 2012; http://emedicine.medscape.com/article/207097-overview. Accessed 10/1/2013.
  2. Waldenström's Macroglobulinemia. Lymphoma Research Foundation. 2012; http://www.lymphoma.org/site/pp.asp?c=bkLTKaOQLmK8E&b=6300163. Accessed 10/1/2013.
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Basic Information

  • Genetics Home Reference (GHR) contains information on Waldenstrom macroglobulinemia. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Waldenstrom macroglobulinemia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Waldenstrom's macroglobulinaemia
  • Lymphoplasmacytic lymphoma
  • Waldenstrom's syndrome
  • Macroglobulinemia of Waldenstrom
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.