Other Names for this Disease
- Intestinal lipodystrophy
- Intestinal lipophagic granulomatosis
- Secondary Non-tropical Sprue
- Tropheryma whippelii infection
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 The disorder usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. In the gastrointestinal system it interferes with the body's ability to absorb certain nutrients. This leads to a condition known as malabsorption. Whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system. It is caused by infection from bacteria called Tropheryma whippelii. When recognized and treated, Whipple disease can usually be cured. Untreated, the disease may be fatal.Whipple disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats.
Last updated: 12/8/2015
- NINDS Whipple's Disease Information Page. National Institute of Neurological Disorders and Stroke (NINDS). March 22, 2011; http://www.ninds.nih.gov/disorders/whipples/whipples.htm. Accessed 12/8/2015.
- Whipple Disease. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). August 2014; http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/whipple-disease/Pages/facts.aspx. Accessed 12/8/2015.
- Lehrer JK. Whipple's disease. MedlinePlus. May 2014; http://www.nlm.nih.gov/medlineplus/ency/article/000209.htm. Accessed 12/8/2015.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Whipple disease. Click on the link to view a sample search on this topic.