Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Wiskott Aldrich syndrome


Other Names for this Disease
  • Aldrich syndrome
  • Eczema thrombocytopenia immunodeficiency syndrome
  • Eczema-thrombocytopenia-immunodeficiency syndrome
  • IMD 2
  • Immunodeficiency 2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

What is Wiskott Aldrich syndrome and what does it do to the body?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is Wiskott Aldrich syndrome?

Wiskott Aldrich syndrome (WAS) is a condition characterized by immunodeficiency and reduced ability to form blood clots. It primarily affects males. Signs and symptoms include easy bruising or bleeding due to a decrease in the number and size of platelets; susceptibility to infections, immune disorders and inflammatory disorders; and an increased risk for some cancers (such as lymphoma). Eczema is common in affected people. WAS is caused by mutations in the WAS gene and is inherited in an X-linked manner.[1] Treatment may depend on severity and symptoms in each person, but stem cell transplantation is the only known cure.[2]
Last updated: 4/10/2015

What are the signs and symptoms of Wiskott Aldrich syndrome?

People with Wiskott Aldrich syndrome (WAS) have a decrease in the number and size of blood cells involved in clotting (platelets), which is called microthrombocytopenia. This is typically present from birth and can lead to easy bruising or episodes of prolonged bleeding after minor trauma. Eczema, patches of red, irritated skin, is common in affected people. People with WAS also have an increased risk of infections due to dysfunction of many types of immune cells. Some people develop autoimmune disorders, which occur when the immune system mistakenly attacks the body's own tissues and organs. There is also an increased risk of developing some types of cancer, such as lymphoma.[1]
Last updated: 4/10/2015

References
Other Names for this Disease
  • Aldrich syndrome
  • Eczema thrombocytopenia immunodeficiency syndrome
  • Eczema-thrombocytopenia-immunodeficiency syndrome
  • IMD 2
  • Immunodeficiency 2
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.