- Xeroderma pigmentosa
Your QuestionIt there a cure for xeroderma pigmentosum? If there's no cure, can it at least be treated?
We have identified the following information that we hope you find helpful. If you still have questions, please contact us.
Questions on this page
- Protection from ultraviolet light
- Frequent skin and eye examinations
- Prompt removal of cancerous tissue
- Neurological examination
- Psychosocial care
Small, premalignant skin lesions such as actinic keratoses can be frozen with liquid nitrogen. Larger areas of sun-damaged skin can be treated with topical 5-fluorouracil or imiquimod. In rare cases, therapeutic dermatome shaving or dermabrasion is used to remove damaged superficial epidermal layers. Skin cancers can be treated using standard treatment protocols, including electrodesiccation and curettage (scrapes away the lesion and uses electricity to kill any remaining cells), surgical excision, or chemosurgery. High dose oral isotretinoin or acitretin can be used to prevent new cancers. Cancers of the eyelids, conjunctiva, and cornea are usually treated surgically. Corneal transplantation may be necessary for those with severe keratitis and corneal opacity.
More detailed information about the treatment of XP may be accessed through the following online resources:
- Xeroderma pigmentosum. Genetics Home Reference (GHR). May 2010; http://ghr.nlm.nih.gov/condition/xeroderma-pigmentosum.
- Kenneth H Kraemer and John J DiGiovanna. Xeroderma Pigmentosum. GeneReviews. February 13, 2014; https://www.ncbi.nlm.nih.gov/books/NBK1397/.
- Berman K. Xeroderma pigmentosum. MedlinePlus. April 14, 2015; https://www.nlm.nih.gov/medlineplus/ency/article/001467.htm.
- Understanding Xeroderma Pigmentosum. NIH Clinical Center. 2006; http://www.cc.nih.gov/ccc/patient_education/pepubs/xp7_17.pdf.