Other Names for this Disease
- Pancreatic ulcerogenic tumor syndrome
- Z E syndrome
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gastrinomas in the pancreas and duodenum (part of the small intestine) cause high levels of the hormone gastrin in the blood. High levels of gastrin then cause production of too much stomach acid. Signs and symptoms may include abdominal pain, peptic ulcers, vomiting blood, and diarrhea. The tumors are sometimes cancerous and may spread to other areas of the body. In most cases, the cause of ZES is unknown. However, about 25-30% of gastrinomas are caused by an inherited condition called multiple endocrine neoplasia type 1 (MEN1). Treatment for ZES may include medication to reduce the production of stomach acid, and surgery for peptic ulcers or to remove tumors.Zollinger-Ellison syndrome (ZES) is a condition in which tumors called
Last updated: 1/14/2014
- David C. Dugdale, III and George F. Longstreth. Zollinger-Ellison syndrome. MedlinePlus. November 11, 2010; http://www.nlm.nih.gov/medlineplus/ency/article/000325.htm. Accessed 1/14/2014.
- Elliot M. Livstone. Pancreatic Endocrine Tumors. Merck Manuals. October, 2012; http://www.merckmanuals.com/professional/gastrointestinal_disorders/tumors_of_the_gi_tract/pancreatic_endocrine_tumors.html?qt=&sc=&alt=. Accessed 1/14/2014.
- Zollinger-Ellison Syndrome. National Digestive Diseases Information Clearinghouse (NDDIC). December 24, 2013; http://www.digestive.niddk.nih.gov/ddiseases/pubs/zollinger/. Accessed 1/14/2014.
- Zollinger-Ellison Syndrome. National Digestive Diseases Information Clearinghouse (NDDIC). May 10, 2012; http://digestive.niddk.nih.gov/ddiseases/pubs/zollinger/. Accessed 10/28/2012.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Digestive Diseases Information Clearinghouse (NDDIC), part of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), offers information on this condition. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Zollinger-Ellison syndrome. Click on the link to view a sample search on this topic.